Pukala Research Group

Research in the Pukala laboratories is focused on developing analytical and bioorganic chemistry approaches, primarily utilising mass spectrometry, to provide new insight into the structure, function and interactions of macromolecules important in biology.


We develop and utilise a range of mass spectrometry based approaches, including proteomics, native and ion mobility-mass spectrometry, to investigate biomacromolecules at all levels of structure. 

Mass spectrometry for structural biology

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We have a focus on implementing novel chemical bioconjugation strategies to 

 enhance detection and structural characterisation of biomacromolecules by mass spectrometry.

Bioconjugation chemistry


Our goal is to apply the innovative biophysical and bioorganic chemistry approaches developed in the Pukala laboratories to address interesting
biological problems.

Biological applications